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Cloud-Clone corp
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Strathmann Biotec AG
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Image Search Results
Journal: Frontiers in Cell and Developmental Biology
Article Title: Fibroblast Growth Factor 2 Promotes Bladder Hypertrophy Caused by Partial Bladder Outlet Obstruction
doi: 10.3389/fcell.2021.630228
Figure Lengend Snippet: Fgf2 expression in the development of PBOO and correlation with clinical data. Venny plot (A) show that Fgf2 and Gas6 were common among high expression in week 4, low expression in week 5 PBOO rat and characteristic for secreted protein. Fgf2 expressed in free-disease bladder tissues (B) . Fgf2 expressed in different cell types of bladder tissues (C) . The level of Fgf2 in rat serum ( n = 3, female) from 0∼6 weeks (D) . Western blot show Fgf2 expression in normal, week 4 and week 5 PBOO rat bladder tissues (E) . Fgf2 promote smooth muscle cell and fibroblasts proliferation in CCK8 assay (F) . Heatmap plot show 7 low and 10 high expression gene were distributed between PBOO and normal bladder tissues (G) . GSEA analysis show three major pathway changes in PBOO rat bladder tissues compared normal (H–J) . BPH patients exhibited higher expression levels of FGF2 (K) and BDNF (O) in the serum. Pearson correlation between the level of FGF2 in serum of BPH patients and prostate volume (L) , age (M) and BMI (N) . Pearson correlation between the level of BDNF in serum of BPH patients and prostate volume (P) , age (Q) , and BMI (R) . *** p < 0.001.
Article Snippet: Enzyme-linked immunosorbent assay (ELISA) kits for rat serum BDNF (SEA011Hu and SEA011Ra) and
Techniques: Expressing, Western Blot, CCK-8 Assay